Cialis: an eternal life

To live eternally problem impracticable, but the life present is in your arms. If you ever thought, that we can not enjoy sex of more than 45-50 years you deeply are mistaken, believe. You can enjoy the sexual life of the whole 100 years. Sex undoubtedly - one of the best gifts of the nature, sex was and remains an integral part of our life since Adam and Eve's times.

The man constantly aspires to sex communications, but there are many factors which become a barrier such as age, hormonal disbalanses, a society, money and many other things. Medicinal grasses, meditation, yoga, and the man always searched for an additional stimulator, for the help in its sexual disturbances.

What is the erectile dysfunction?

Erectile dysfunction - man's disturbance, in other words the man not in a status to support an erection some time demanded for end sexual intercourse. Before erectile dysfunction was known as an impotence. There is a considerable quantity of the reasons of sex dysfunction: psychological factors, hormonal factors, arterial or muscular. The illnesses, bound to it are a diabetes mellitus, depression, etc.

What is the Brand cialis?

Brand cialis - the best medicine for treatment of erectile dysfunction. FDA has approved a preparation a Cialis original, achieved surprising success in treatment of sex powerlessness. Brand Cialis, inhibits enzyme PDE 5, “It means, that after tablet acceptance (tadalafil Generic Cialis of 20 mg), in a current of 20-30 minutes is received a natural erection”. The operating inhibitor of enzyme named which allocates nitrogen for the nervous terminations from which unstriated muscles are relaxed and blood flows to a sexual member … an erection you awake are happy. This product in common framed by companies Eli Lilly was known under the trade mark a Tadalafil, gone on sale 2003.

To whom a preparation the Cialis can benefit?

There is a widespread myth, that the person accepting a preparation will have an erection, but it not so. Medical product action begins only at physical activity. Men with a cancer of a prostate which it have removed, in most cases continue a healthy and safe life, but procedure often leads to man's powerlessness. Recently carried out research Viagra shows, that a Sildenafil, a popular preparation for treatment of erectile dysfunction, can restore a potency lost at operation.

FDA Warns Consumers to Avoid Man Up Now Capsules

The U.S. Food and Drug Administration (FDA) is warning consumers that Man Up Now capsules may dangerously lower blood pressure.

Man Up Now is marketed as a dietary supplement for sexual enhancement, but has been found to contain sulfoaildenafil, a chemical similar to sildenafil, the active ingredient in Viagra and can dangerously lower blood pressure.
Consumers may mistakenly assume Man Up Now is harmless as it claims to be “herbal” and “all natural.” Consumers who have Man Up Now capsules should stop using them immediately.
Images: 7 reasons causing sexual problems
Sulfoaildenafil, like sildenafil, may interact with prescription drugs such as nitrates, including nitroglycerin, and cause dangerously low blood pressure. When blood pressure drops suddenly, the brain is deprived of an adequate blood supply that can lead to dizziness or lightheadedness.
Man Up Now, distributed by Synergy Distribution LLC, is sold on Internet sites, online marketplaces, and possibly in retail outlets in single, double, and triple blister packs, and in six-, 12-, and 30-count capsule bottles.
To date, the FDA is not aware of any adverse events associated with the use of the product. However, sexual enhancement products that claim to work as well as prescription products, but that contain prescription strength drugs, are likely to expose unknowing consumers to unpredictable risks and the potential for injury or death.
The FDA advises consumers who have experienced any negative side effects from sexual enhancement products to consult a health care professional and to safely discard the product. Consumers and health care professionals should report adverse events to the FDA’s MedWatch Adverse Event Reporting program either online, by regular mail or by fax:
Complete and submit the report online: www.fda.gov/MedWatch/report.htm
Download form or call 800-332-1088 to request a reporting form, then complete and return to the address on the pre-addressed form or submit by fax to 800-FDA-0178.
For more information:

Folic Acid Boosts Sperm

Guardian reports. Women have long been encouraged to take folic acid when trying for a baby, but a new study has found "a link between high levels of the nutrient in men's diets and the genetic quality of their sperm," the newspaper says.
The study behind the story is a small cross-sectional survey of 89 healthy, non-smoking male volunteers. It found a link between folic acid intake and the frequency of abnormalities in sperm cells. By virtue of its design, limited conclusions can be drawn from the study and the results may have arisen by chance. Randomised controlled trials are needed to explore this relationship properly.
Where did the story come from? Dr Suzanne Young and colleagues from the University of California, the Lawrence Livermore National Laboratory, and the Lawrence Berkeley National Laboratory carried out this research. The study was funded by the National Institutes of Health, the Environmental Protection Agency and the United States Department of Energy. It was published in Human Reproduction, a peer-reviewed medical journal.
What kind of scientific study was this? Healthy sperm should have one copy of each sex chromosome (X or Y). Aneuploidy means the sperm contains an abnormal number of chromosomes. About 1% to 4% of a healthy male's sperm have some type of abnormality of this kind. Why these abnormalities happen is poorly understood and the role of nutrition has not been explored.
In this small cross-sectional study, researchers contacted 97 volunteers who were healthy, non-smoking, current or retired employees of a university research laboratory. Participants were sent a questionnaire to collect information about their sociodemographic characteristics, medical and reproductive history, and lifestyle. The questionnaire also included a food frequency section that looked at the type and amount of foods eaten daily. Participants were also sent instructions for semen collection, a sterile container and a protective thermos to provide a sperm sample. To ensure completion and accuracy, participants were contacted by telephone and the food frequency question was completed within a week of providing the sperm sample.
The researchers analysed the sperm samples to determine whether they had any abnormalities. They looked for abnormalities associated with the genetic disorders Klinefelter's, triple X, XYY, Turner and Down's syndromes. Eighty-nine men were available for analysis after excluding those with low sperm counts or unusable food consumption data. The researchers used statistical methods to assess whether there was any relationship between the frequency of different types of abnormality (per 10,000 sperm) and low, moderate or high daily intake (from diet and through supplements) of different micronutrients (vitamin C, vitamin E, beta-carotene, folate and zinc). The researchers also took into account some factors that could also affect sperm health, e.g. disease history, body mass index, occupational history and use of tobacco, alcohol or caffeine, among other exposures.
What were the results of the study? The researchers found that several micronutrients were associated with a lower frequency of different abnormalities. High folic acid intake was associated with 19% fewer abnormalities (all types) than moderate intake and 20% fewer than men with a low micronutrient intake. There were also reductions in specific types of abnormality. For example, there were 26% fewer sperm with no sex chromosome in the high-intake group compared with the low-intake group. There were also 30% fewer sperm with two X chromosomes (associated with triple X syndrome) and abnormalities on chromosome 21 (associated with Down's syndrome) in the high-intake group compared with the moderate-intake group.
However, men in the low-intake folic acid group had fewer sperm with two X chromosomes (associated with triple X syndrome) and abnormalities on chromosome 21 (associated with Down's syndrome) than in the moderate-intake group. High total zinc intake reduced the frequency of two X chromosomes by about 50% compared with the moderate-intake group and 39% compared with the low-intake group. Zinc was not associated with lowering the risk of other abnormalities. Vitamin C and vitamin E had no association with sperm abnormalities, but high beta-carotene intake reduced YY abnormalities.
The researchers calculated that there was a reduction of 3.6% in the frequency of total abnormalities for every 100 microgram increase in daily total folate. When considering the different types of abnormalities separately, the magnitude of reduction was similar for two X chromosomes, no chromosomes and abnormality on chromosome 21.
There was a reduction of 2.8% in sperm having two Y chromosomes for every 1,000 microgram increase in daily total beta-carotene.
What interpretations did the researchers draw from these results? The researchers conclude that micronutrient intake affects male reproductive health. They say that they have found that total folic acid intake is associated with a statistically significant reduction in frequency of sperm abnormalities in healthy males. They say that there are "no consistent relationships between intakes of zinc or the antioxidant vitamin C, vitamin E or beta-carotene on the frequencies of aneuploid sperm".
What does the NHS Knowledge Service make of this study?
This is a small cross-sectional study and has some limitations, mainly those associated with this type of study design:
* Cross-sectional studies cannot establish causal links between factors. This study cannot prove that low levels of micronutrient intake cause abnormalities in sperm. Randomised controlled trials that compare men who take micronutrients with those who do not would be the most robust way to answer this question.
* As the researchers point out, the intake of folic acid varied with the intake of other micronutrients, so they "could not definitively determine whether the results derived specifically from folate intake". Again, randomised controlled trials would better establish this.
* The researchers point out that the men involved in the study were high supplement-users (e.g. consuming more than double the recommended daily intake for folic acid) so, from these results, the importance of micronutrients from diet only are unclear. The findings may have limited application to members of the general population as the participants were a healthy non-smoking group.
* The food frequency questionnaire has some problems, particularly how well it estimates the amount of food eaten. As the authors say, intake of the different nutrients measured through the questionnaire may not reflect the concentrations in the blood or cells and in sperm production processes.
* Performing a number of different analyses on a dataset, as the researchers here did, increases the likelihood that positive findings have arisen by chance only. The researchers don't appear to have adjusted for this. However, they say that the consistent associations that different analyses found between folate intake and different types of sperm aneuploidy "argue that the finding is not simply due to chance".
The truth is that, in science, it is rarely 100% certain that a result is not due to chance. Without correcting for these separate analyses, there is an increased likelihood that chance is responsible for the positive results here.
The study gives some evidence of a link between folate intake and sperm abnormalities. However, larger studies, particularly those with a more robust study design (e.g. randomised controlled trials), would give more confidence that any relationship between folic acid and sperm quality was real.

Sexually abused men 10 times more likely to contemplate suicide

Sexual abuse in childhood increases the risk of suicide in men by up to ten times, say researchers from the University of Bath. A recent study of Australian men has found that those who were sexually abused as children are more likely than women to contemplate taking their own lives.
Whilst gender and mental health problems are the most important risk factors for contemplating suicide, it is increasingly acknowledged that traumatic experiences such as childhood sexual abuse may be a significant risk factor.
Dr Patrick O’Leary and Professor Nick Gould from the University’s Department of Social & Policy Sciences conducted a series of surveys and face-to-face interviews with men in a study funded by the University of South Australia. The findings have been published online in the peer-reviewed British Journal of Social Work.
They found that men who were sexually abused as children were up to ten times more likely to have suicidal tendencies; many of these men had not been clinically diagnosed as depressed.
Dr O’Leary said: “Childhood sexual abuse is an under-recognised problem in men - most of the studies exploring the link with suicide have been in women.
“Men are particularly vulnerable because they don’t like to talk to others about their problems. It’s difficult for anyone to come to terms with traumatic experiences such as childhood sexual abuse, but for men the stigma is worse because they don’t tend to confide in their friends as much.
“Many suffer feelings of failure and isolation and think that it is a sign of weakness to discuss their past abuse with others. Men also tend to visit their doctors less frequently, so those who are at risk of suicide often slip under the radar of the healthcare system.
“Men are particularly vulnerable to suicide and are three and a half times more likely than women to end their own lives, with more than 2,000 men dying as a result of suicide in the UK each year. However it is estimated that for every suicide, there are between 20 and 25 failed attempts.
“We carried out the study in Australia, which shares a similar ‘stiff upper lip’ culture that we see in the UK. We’re planning to do our next study in the UK to see if there are any differences.”
Dr O’Leary suggested that lives could be potentially saved if abuse victims are identified earlier.
He explained: “The abuse that these men have suffered as children often sees them attempting to cope by suppressing the experience through substance abuse, alcohol abuse and obsessive behaviour, with many ending up in the criminal justice system.
“Greater awareness in the healthcare and criminal justice systems will help identify those who are at risk and give them treatment before it is too late.”

Don’t Mix Erectile Dysfunction Pills With These Medications

Group warns impotence drug users by listing 56 medications that may cause dangerous interactions or alter the effectiveness of erectile dysfunction drugs.
People who take three well-known erectile dysfunction medications should be extremely careful if they take any of 56 other drugs, including many commonly prescribed anti-angina and certain blood pressure medications, grapefruit juice and St. John’s Wort, Public Citizen writes in a new January article posted on its WorstPills.org Web site.
The three erectile dysfunction drugs are Viagra (chemical name sildenafil), Cialis (tadalafil) and Levitra (vardenafil). The 56 drugs fall into three categories: 1) those that can cause a life-threatening drop in blood pressure when taken with erectile dysfunction drugs; 2) those that prevent the body from eliminating erectile dysfunction drugs, thereby leading to an overdose; and 3) those that speed up the metabolism of the erectile dysfunction drugs, thereby reducing their effectiveness. Grapefruit juice also is listed in the second category because it acts like a drug in this circumstance.
“Those who take erectile dysfunction drugs are generally older men, who are more likely to be taking other medications as well,” said Dr. Sidney Wolfe, director of the Health Research Group at Public Citizen. “It is critical that they be aware of the potential for dangerous interactions.”
Erectile dysfunction drugs cause blood vessels to dilate, an effect that is magnified when taken with blood pressure medications, which also dilate blood vessels. So men who take blood pressure medications such as Flomax and Cardura should avoid erectile dysfunction drugs, Wolfe said. The combination can cause a dangerous drop in blood pressure that could lead to a heart attack or stroke.
Other drugs, such as erythromycin and nefazodone, inhibit an enzyme that metabolizes erectile dysfunction medications, thereby causing a build-up of the erectile dysfunction drugs to higher levels. Still other medications, like nafcillin, phenobarbital and 13 other drugs, increase the activity of the enzyme, rendering the erectile dysfunction drugs less effective. St. John’s Wort, an herbal supplement, also falls into this third category because it has a negative, drug-like effect when used with erectile dysfunction drugs.
The complete list of 56 drugs is at Public Citizen’s WorstPills.org, along with an explanatory article from Worst Pills, Best Pills, a monthly newsletter available in print and electronic formats through the subscription site WorstPills.org. The article about harmful interactions with erectile dysfunction drugs will be available free for the next seven days. The site has other searchable information about the uses, risks and adverse effects associated with prescription medications.
WorstPills.org is an unbiased analysis of information from a variety of sources – including well-regarded medical journals and unpublished data obtained from the Food and Drug Administration – that allows Public Citizen to warn the public about potentially dangerous drugs long before they are banned or adequately regulated by the federal government. For example, Public Citizen warned consumers about the dangers of Vioxx, ephedra, Baycol and Propulsid years before they were pulled from the market.

Lilly ICOS' Cialis (tadalafil) Improves Erectile Function in ED Patients

Erectile Dysfunction Treatment

Lilly ICOS LLC announced data today from an open-label clinical trial showing Cialis (tadalafil)(1) improved erections in more than three- quarters of men who were suffering from erectile dysfunction (ED) and one or more comorbid conditions. These comorbidities include cardiovascular disease (including hypertension), diabetes, depression, hyperlipidemia, and prostate disease (including those who had undergone prostatectomy). On average, nearly 50 percent of all attempts resulted in an erection that lasted long enough to have successful sexual intercourse when patients were treated with Cialis 20 mg. This is compared to approximately 17 percent of attempts at baseline for this patient group. These data will be presented today at the 100th Annual Meeting of the American Urological Association (AUA).
"Treatment of erectile dysfunction in men with comorbid conditions is a challenge. It is exciting to see such positive results in this group of patients, who had a relatively high degree of severe erectile dysfunction and many of whom had multiple comorbidities," said Irwin Goldstein, M.D., Professor of Urology and Gynecology at the Boston University School of Medicine. "The findings confirm that Cialis improved erectile function in men with erectile dysfunction even when associated with significant comorbid conditions. Also, these patients tolerated treatment with Cialis very well."

Study Design and Key Findings on Erectile Dysfunction

The MOMENTUS study (Multiple Observations in Men with erectile dysfunction in National Tadalafil Study in the United States) is a multi-center, open-label study that evaluated the efficacy and safety of Cialis 20 mg in 1,911 American men with ED who were enrolled into eight predefined groups. In this study, after a four-week treatment-free period to determine baseline erectile dysfunction, patients were instructed to take Cialis 20 mg as needed prior to sexual activity (not more than one dose a day) for a period of 12 weeks. The subgroup discussed here included 155 patients, mean age 65, who had significant comorbid conditions; many of these patients also had severe erectile dysfunction at baseline (51.9 percent). This subgroup comprised patients who met the enrollment criteria for the MOMENTUS trial but who could not be included in any other predefined group.
In the subgroup, 77.4 percent of patients reported an improvement in their erections after taking Cialis 20 mg based on the Global Assessment Questions (GAQ)(2), question one (Has the treatment you've been taking during this study improved your erections?). They also showed a 7.6 point improvement from the baseline score of 11.48 in the Erectile Function (EF) Domain Score of the International Index of Erectile Function (IIEF)(3). It is generally considered that an improvement of four points or more in the EF domain score reflects a clinically meaningful change(4).
After taking Cialis 20 mg, patients reported an increase from baseline in erections that resulted in "successful sexual intercourse" based on positive per patient response to Sexual Encounter Profile (SEP)(5) question three (Did your erection last long enough for you to have successful sexual intercourse?). On average, nearly half (49.4 percent) of the attempts resulted in an erection that lasted long enough for successful sexual intercourse, compared to the percentage at baseline of 16.9.
"Cialis provides a meaningful therapeutic benefit with regards to erectile function in men suffering fromerectile dysfunction and significant comorbid conditions," said Sanjeev Ahuja, M.D., Associate Medical Director, Eli Lilly and Company. "Men who have ED should visit their doctor to discuss their sexual health and their overall health. This will give their doctor the opportunity to do a complete exam, during which significant health problems may be detected and addressed, and treatment options for erectile dysfunction can be discussed."
The most commonly reported side effects in the patients in this group were headache, flushing, nasal congestion, back pain, and upset stomach. Discontinuations due to adverse events in this group were three percent and similar to previously reported discontinuation rates in Cialis clinical trials. Not included in this clinical trial were patients with certain serious underlying cardiovascular conditions, including recent myocardial infarction, uncontrolled arrhythmias, hypotension (<90/50 mm Hg), uncontrolled hypertension (>170/100 mm Hg), unstable angina or angina occurring during sexual intercourse, or those who recently suffered a stroke or had severe heart failure.